Table - Lack of Transmission of Chronic Wasting Disease Prions to Human Cerebral Organoids - Volume 30, Number 6—June 2024 - Emerging Infectious Diseases journal (2024)

Bradley R. Groveman¹, Katie Williams¹, Brent Race, Simote Foliaki, Tina Thomas, Andrew G. Hughson, Ryan O. Walters, Wenquan Zou, and Cathryn L. Haigh

Author affiliations: Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana, USA (B.R. Groveman, K. Williams, B. Race, S. Foliaki, T. Tomas, A.G. Hughson, R.O. Walters, C.L. Haigh); Jiangxi Academy of Clinical Medical Sciences, The First Affiliated Hospital of Nanchang University, Nanchang, China (W. Zou)

Inoculum details used in the study of attempted CWD prion transmission to human cerebral organoids*

Sample	Name	log LD₅₀/mg brain†	log SD₅₀/mg brain‡
Human normal brain hom*ogenate	hNBH	Negative	Negative
Human sporadic CJD MV2	CJD	ND	6.9
Deer normal brain hom*ogenate	dNBH	Negative	Negative
Whitetail deer CWD§ (pool of 7)	dCWD1	5.6 (WTD)	6
Mule deer CWD¶ (pool of 6)	dCWD2	5.7 (MD)	6.2
Elk normal brain hom*ogenate	eNBH	Negative	Negative
Elk CWD# (pool of 6)	eCWD	5.3	6.5

*CJD, Creutzfeldt-Jakob disease; CWD, chronic wasting disease; LD₅₀, 50% lethal dose; negative,negative control; ND,not done; SD₅₀, 50% seeding dose.†Adapted from Race et al. (29). ‡Inocula. §WTD-1 in nomenclature as found in (29).¶MD-1 in nomenclature as found in (29)#Elk-2 in nomenclature as found in (29).

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¹These authors contributed equally to this article.

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