Summary
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- Official Symbol
- Idi2provided by MGI
- Official Full Name
- isopentenyl-diphosphate delta isomerase 2provided by MGI
- Primary source
- MGI:MGI:2444315
- See related
- Ensembl:ENSMUSG00000033520 AllianceGenome:MGI:2444315
- Gene type
- protein coding
- RefSeq status
- VALIDATED
- Organism
- Mus musculus
- Lineage
- Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
- Also known as
- IPPI2; 4833405L16Rik
- Summary
- Predicted to enable isopentenyl-diphosphate delta-isomerase activity. Acts upstream of or within negative regulation of cholesterol biosynthetic process. Predicted to be located in peroxisome. Predicted to be active in cytoplasm. Orthologous to human IDI2 (isopentenyl-diphosphate delta isomerase 2). [provided by Alliance of Genome Resources, Apr 2022]
- Expression
- Low expression observed in reference dataset See more
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Genomic context
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See Idi2 in Genome Data Viewer
- Location:
- 13 A1; 13 3.63 cM
- Exon count:
- 5
Annotation release | Status | Assembly | Chr | Location |
---|---|---|---|---|
RS_2024_02 | current | GRCm39 (GCF_000001635.27) | 13 | NC_000079.7 (9002899..9010981) |
108.20200622 | previous assembly | GRCm38.p6 (GCF_000001635.26) | 13 | NC_000079.6 (8952863..8960935) |
Chromosome 13 - NC_000079.7
Genomic regions, transcripts, and products
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Go to reference sequence details
Go to nucleotide: Graphics FASTA GenBank
Expression
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See details
- Project title: Mouse ENCODE transcriptome data
- Description: RNA profiling data sets generated by the Mouse ENCODE project.
- BioProject: PRJNA66167
- Publication: PMID 25409824
- Analysis date: n/a
Bibliography
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Related articles in PubMed
- Isopentenyl-diphosphate isomerases in human and mouse: evolutionary analysis of a mammalian gene duplication. Breitling R, et al. J Mol Evol, 2003 Sep. PMID 14629038
- IDI2, a second isopentenyl diphosphate isomerase in mammals. Clizbe DB, et al. J Biol Chem, 2007 Mar 2. PMID 17202134
- A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo. Şişecioğlu M, et al. J Lipid Res, 2015 Aug. PMID 26108225, Free PMC Article
- Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
- High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
See all (12) citations in PubMed
GeneRIFs: Gene References Into Functions
What's a GeneRIF?
- significant positive fitness effect of IDI2, revealed by the pattern of sequence conservation, as well as its specific expression pattern underscores the importance of the IDI gene duplication
Title: Isopentenyl-diphosphate isomerases in human and mouse: evolutionary analysis of a mammalian gene duplication.
Submit: New GeneRIF Correction
Pathways from PubChem
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General gene information
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Related pseudogene(s)
- 1 foundReview record(s) in Gene
Gene Ontology Provided by MGI
Function | Evidence Code | Pubs |
---|---|---|
enables isomerase activity | IEA Inferred from Electronic Annotation | |
enables isopentenyl-diphosphate delta-isomerase activity | IBA Inferred from Biological aspect of Ancestor | |
enables isopentenyl-diphosphate delta-isomerase activity | ISO Inferred from Sequence Orthology | |
enables metal ion binding | IEA Inferred from Electronic Annotation |
Component | Evidence Code | Pubs |
---|---|---|
is_active_in cytoplasm | IBA Inferred from Biological aspect of Ancestor | |
located_in intracellular membrane-bounded organelle | ISO Inferred from Sequence Orthology | |
located_in peroxisome | ISO Inferred from Sequence Orthology |
General protein information
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- Preferred Names
- isopentenyl-diphosphate delta-isomerase 2
- Names
- IPP isomerase 2
- isopentenyl diphosphate delta-isomerase type 2
- isopentenyl pyrophosphate isomerase 2
- isopentenyl-diphosphate Delta-isomerase 2
- NP_796171.1
-
- EC 5.3.3.2
NCBI Reference Sequences (RefSeq)
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RefSeqs maintained independently of Annotated Genomes
These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.
mRNA and Protein(s)
-
NM_177197.5 → NP_796171.1 isopentenyl-diphosphate delta-isomerase 2
See identical proteins and their annotated locations for NP_796171.1
Status: VALIDATED
- Source sequence(s)
- AC124732
- Consensus CDS
- CCDS26235.1
- UniProtKB/Swiss-Prot
- Q4FZF0, Q8BFZ6
- Related
- ENSMUSP00000036621.2, ENSMUST00000038598.3
- Conserved Domains (2) summary
-
- COG1443
Location:18 → 215 - Idi; Isopentenyldiphosphate isomerase [Lipid transport and metabolism]
- cl00447
Location:18 → 227 - Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
- COG1443
RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02
The following sections contain reference sequences that belong to a specific genome build. Explain
Reference GRCm39 C57BL/6J
Genomic
-
NC_000079.7Reference GRCm39 C57BL/6J
- Range
- 9002899..9010981
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
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Nucleotide | Protein | Strain | |
---|---|---|---|
Heading | Accession and Version |
Protein Accession | Links | |
---|---|---|
GenPept Link | UniProtKB Link | |
Q8BFZ6.1 | GenPept | UniProtKB/Swiss-Prot:Q8BFZ6 |
Additional links
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Gene LinkOut
The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.
- MilliporeSigma
- Bgee database
- BioGPS
- BioGRID Open Repository of CRISPR Screens (ORCS)
- CREB Target Gene Database
- CTD: Comparative Toxicogenomics Database
- Eukaryotic Promoter Database
- GlyGen glycoinformatics resource
- Guide to Pharmacology
- Ingenuity Pathways Analysis
- InnateDB
- Kyoto Encyclopedia of Genes and Genomes
- OMA Browser: Orthologous MAtrix
- OrthoDB catalog of orthologs
- PANTHER Classification System
- Addgene Non-profit plasmid repository
- Creative Biogene
- ExactAntigen/Labome
- GenScript latest version of gene cDNA ORF Clone
- GeneCopoeia Inc.
- OriGene
- InterologFinder.org
- Reactome